3. - A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 82a292-NjljY the serum HIV antibody test may be negative at the time of clinical presentation. the serum HIV antibody test may be negative at the time of clinical presentation. Meningococcal disease can lead to death in as little as a few hours. The genus Neisseria contains two major human pathogens: N.meningitidis (Nm) causes meningitis and sepsis, and N.gonorrhoeae (Ng) causes the sexually transmitted disease gonorrhoea. Meningitis: Inflammation around the brain or spinal cord. Contagio directo e intimo. The pathogenic species are Neisseria meningitidis (meningococcus), a major cause of meningitis and bacteremia, and Neisseria gonorrhoeae (gonococcus), the cause of . Disease due to N. meningitidis occurs in two peaks; infants less than 1 year of age and in the elderly. It can also be caused by parasites . Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae type b (Hib) are the predominant causative pathogens in adults.. The two major pathogenic species are Neisseria gonorrhoeae and N.meningitidis, which are closely related and colonize only humans.Pili of pathogenic Neisseria are long filamentous structures of the type IV fimbria family that extend from the bacterial . HIV (166) 3. The formulation of a broadly protective vaccine to prevent the serogroup B Neisseria meningitidis (MenB) disease is still an unmet medical need. . Streptococcus pneumoniae, Neisseria meningitidis, S. agalactiae, Haemophilus influenzae, E. coli. Anaerobic: Veillonella ; spp. Second edition (2011) This manual summarizes laboratory techniques used in the isolation and identification and characterization of Neisseria meningitidis (the meningococcus), Streptococcus pneumoniae (the pneumococcus) and Haemophilus influenzae from the . meningitidis. Depicting Bacterial Genome Sequences GC skew (G-C)/G+C) Genes coded by location & function %G+C Genes shared with E. coli Genes unique to S. typhi Inferrring lateral gene transfer (LGT) from sequence heterogeneity along the chromosome Neisseria meningitidis, 52% G+C (from Tettelin et al. All other cases of bacterial meningitis are Meningitis Created By: VSU Student Health Center Nursing Staff What is Meningitis? Manual for the laboratory identification and antimicrobial susceptibility testing of bacterial pathogens of public health importance in the developing world: Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae, Neisseria gonorrhoeae, Salmonella serotype Typhi, Shigella, and Vibrio cholerae. Death can occur in a few hours. Cryptococcus: The MEPP has decreased sensitivity for : Cryptococcus: and if this disease is a concern a cryptococcal antigen should be ordered. Based on clinical presentation and initial CSF results consider further investigations eg multiplex or specific PCR testing for enterovirus, parechovirus, Neisseria meningitidis, Streptococcus pneumoniae or Herpes simplex virus (HSV) FBE (may be normal), Glucose, Serum sodium, Blood cultures Map: Areas with frequent epidemics of meningococcal meningitis. Low. Morphology Capsulated Gram negative cocci in pairs (diplococci) 0.5 - 1 m in size Kidney shaped, flat sides adjacent Intracellular, usually Non motile Non spore forming. is spread through close contact (coughing or kissing) or lengthy contact (e.g. Prevalencia: todo el ao.Crece a 35, precisa hemina para crecer (factor X). The genus Neisseria contains the two gram-negative cocci which are established human pathogens The genus also contains many commensal species, most of which are harmless inhabitants of the upper respiratory and alimentary tracts. Infectious meningitis can be caused by a bacterial, viral, or fungal infection. The presentation concludes by bringing us up-to-date with an overview of the key ways in which the control of plant disease is achieved, and human involvement in this process. Neisseria meningitidis Preventing Laboratory Exposure: Vaccine available for serogroups A, C, W135 and Y 12% of reported cases in 2008 were from one of these serogroups (77% from serogroup B) Seal plates from patients with possible N. meningitidis (Gram negative diplococci seen) Examine cultures from sterile sites inside safety cabinet He received empirical bacterial meningitis therapy on presentation to the hospital as per local guidelines with 4 g ceftriaxone every 24 h, vancomycin titrated to >20 mg/L and 10 mg . Infection by the bacterium Neisseria meningitidis (meningococcus). PowerPoint Presentation Author: Peter Smith Last modified by: michael.morin Created Date: 5/22/2007 8:20:55 PM Document presentation format: Custom Company: State of Maine - DHS Other titles: Times New Roman Arial Calibri Symbol Microsoft Sans Serif Arial Unicode MS Default Design PowerPoint Presentation Laboratory Methods for the Diagnosis of Meningitis Caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. 2000. NEISSERIA MENINGITIDIS N. meningitidis is a human pathogen which can cause sporadic disease (type B) or epidemics (types A and C). Nutritional profiles of Neisseria gonorrhoeae, Neisseria meningitidis, and Neisseria lactamica in chemically defined media and the use of growth requirements for gonococcal typing. Neisseria meningitidis 15% mortality due to Rx delays Infants, young adults Fatigue, overcrowding Death due to _____ shock Treatment: Vaccine does not cover all strains 2. Value Set Name: Lab Test Name (Meningococcal Disease) Value Set OID: 2.16.840.1.114222.4.11.4176: Value Set Description: lab tests associated with Meningococcal Disease In recent years, significant advances have improved our understanding of the epidemiology and genetic basis of meningococcal disease Gram-positive rods Gram-negative rods Aerobic Large: Bacillus spp Cocco-bacillus: Listeria monocytogenes, Lactobacillus spp NEISSERIA MENINGITIDIS: Diplococo Gram - ,intracelular, oxidasa +, aerobio. Neisseria meningitidis is the leading cause of bacterial meningitis in children and young adults in the United States, with an overall mortality rate of 13 percent, and it is the second most common cause of community-acquired adult bacterial meningitis [].The clinical manifestations of meningococcal disease can be quite varied, ranging from transient fever and bacteremia to . [PMC free article] [Google Scholar] Catlin BW. Neisseria meningitidis (the meningococcus) causes significant morbidity and mortality in children and young adults worldwide through epidemic or sporadic meningitis and/or septicemia. concepto : Neisseria meningitidis Habitat Clasificacin Los meningococos se encuentran, sin producir enfermedad, en la garganta o nasofaringe de individuos sanos (de en 5 a un 20% de la poblacin lo albergan). in dorm rooms or military barracks). Bacterial meningitis is a medical emergency that requires prompt recognition and treatment. Symptoms of septicemia include tiredness, vomiting, chills, severe aches and pain, fast breathing, diarrhea, and a dark rash. Neisseria meningitidis is a pathogenic species of bacteria which causes meningitis and/or septicaemia in children and young adults. We have previously reported the induction of bactericidal and protective antibodies against MenB after immunization of mice with a phage-displayed peptide named 4 L-5. The genus Neisseria consists of gram-negative pathogenic and nonpathogenic bacteria (generally diplococci) that colonize mucosal surfaces. Ab initio techniques were used to identify more stable mimics, and the behavior of the natural Men A monosaccharide in solution was compared to that of a carbasugar analogue by MD simulation and . of Neisseria meningitidis bacteria most commonly seen in the United States (B, C, and Y). NEISSERIA MENINGITIDIS Dr. K V CHAKRADHAR Assistant professor Department of Microbiology NRIIMS. Meningococcal meningitis - cerebrospinal fluid infection. Interpretation. Can infect normally sterile sites, causing invasive disease. 2. Inmvil, saprofito de ORL exclusivamente humana. The bacteria can result in meningitis, blood stream infection or other infections. Distribucin universal. The bacterium responsible for meningitis (Neisseria meningitidis) can also infect the bloodstream, causing another life-threatening condition known as sepsis. Blood and CSF cultures were positive for Neisseria meningitidis serogroup B. Neisseria meningitidis is immediately reportable on first knowledge or suspicion of the diagnosis due to the potential need for prophylaxis of close contacts within 24 hours of suspected diagnosis (suspicion is normally based on gram stain results - see table on page 4). Traditional PowerPoint Presentations on Infective Agents . Como en el caso del gonococo, se ha descrito en el meningococo una enzima capaz de desdoblar la molcula de IgA, subclase 1. Neisseria meningitidis, N. gonorrhoeae, Moraxella catarrhalis Cocco-bacillus: Haemophilus influenzae, Acinetobacter. Meningococcal Disease Five major serogroups A, B, C, Y, and W-135 Transmission via direct contact with respiratory secretions of a nasopharyngeal carrier Most common cause of bacterial meningitis in individuals 2-18 years Approximately 3000 cases each year Mortality rates 10-13% 10% of survivors with severe morbidity -mental retardation Neisseria meningitidis PATOGENIA Los meningococos con pilis se fijan al epitelio respiratorio, en donde se establecen generalmente como microbiota normal. After failing to grow on standard and selective media, Neisseria meningitidis was identified by 16s PCR and subsequently typed as serogroup C. Organisms attach to the epithelial cells of the It is responsible for both sporadic cases of meningitis and epidemics of the disease worldwide, producing considerable morbidity and mortality (Rouphael and Stephens, 2012). Neisseria meningitidis remains a leading cause of meningitis and sepsis. In the Netherlands, the incidence of MenW infections increased 10-fold, from an average of 0.03 per 100,000 population in 2002-2014 to 0.29 . Meningitis can be infectious or it can be caused by injury, cancer, and other noninfectious causes. A man in his 80s presented to the hospital with a 36-hour history of fever, myalgia, bilateral shoulder and right knee pain. Meningitis is a disease process where the protective layers that cover the brain and spinal cord become inflamed. This review provides an update on our understanding of immunity against meningococcal infection. This topic covers non-meningococcal bacterial meningitis acquired by adults in the community; meningitis may also be associated with invasive procedures or head . Knowledge of the meningococ. Neisseria meningitidis, an exclusive pathogen of humans, remains the leading worldwide cause of meningitis and fatal sepsis, usually in otherwise healthy individuals. Times New Roman MS PGothic Arial MS P Wingdings ArialMT Times Blank 1_Blank Chapter 22, part A Portal of entry for CNS and PNS The Nervous System Microbial Diseases of the Nervous System PowerPoint Presentation Bacterial Meningitis Etiologies of Bacterial Meningitis PowerPoint Presentation Haemophilus influenzae Meningitis . NEISSERIA Treatment of meningitis Depends on age ,causal bacteria Urgent ,parenteral Ceftriaxone Neonates: amp+ gm (or ceftriaxone) Sens.testing Anti TB Introduction The Neisseriae are G-ve diplococci Pathogens are:- N.meningitidis N.gonorrhoeae Exacting growth requirements Commensals easy to grow on ordinary media N. gonorrhoeae Obligate parasite of human urogenital tract. Neisseria gonorrhoeae. Neisseria meningitidis-induced discitis at L5-S1 mimicking lumbar disc herniation Previous Article Chronic cavitary pulmonary aspergillosis in an infant A 23-year-old man presented to his general practitioner with a 2-week history of increasing lumbar back pain and left-sided radiation at S1, with progressive motoric loss of function of S1 on . N. meningitidis is classified into 13 distinct serogroups; however, almost all invasive disease in humans is a result of infection with one of 6 serogroups. Approximately 50% of the cases occur in children between 1 and 4 years old. Chapter Review Topics. . Pathophysiology. Category. Strains of types D, X, Y, W135, 129E also cause meningitis. However, this treatment success has a major drawback: a substantially increased susceptibility for life-threatening Neisseria meningitidis infections. Molecular Mechanism of Resistance. Intermediate Non-wild-Type Nonsusceptible Not applicable Resistant Susceptible Susceptible-dose dependent SYN-R SYN-S Wild-Type. (See "Bacterial meningitis in children older than one . GNC Oxidase (+) Neisseria gonorrhoeae Neisseria meningitidis Moraxella catarrhalis Opportunistic glucose (dextrose) maltose (+) (-) (-) sucrose lactose (-) glucose . Joint fluid aspirates from his shoulders and right knee isolated Gram-negative diplococci. Neisseria Gram negative coccus Dr. Hala Al Daghistani Important Human Pathogens Neisseria gonorrhoeae Neisseria meningitidis General Neisseria meningitidis. A 22-year-old man presented to a hospital emergency department with symptoms of bacterial meningitis but without focal neurology. Staphylococcus (192, 193) High. In March 2017, a patient with necrotising fasciitis caused by Neisseria meningitidis serogroup W (MenW) clonal complex 11 was diagnosed in the Netherlands. Neisseria and Chlamydia Ken B. Waites, M.D., F(AAM) September, 2008 Objectives To review and discuss microbiological characteristics epidemiology virulence factors associated diseases laboratory detection Of: Neisseria meningitidis Neisseria gonorrhoeae Chlamydia trachomatis Chlamydophila pneumoniae Chlamydophila psittaci Author summary Bacteriophages are bacterial viruses, which in some cases encode for virulence factors and increase bacterial virulence. Complement C5 inhibitor eculizumab has a great impact on the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH). Both stringent (genus & species of top 3 are the same with 1.7 score) and relaxed (genus & species of top 1 with 1.7 score) MALDI-ToF acceptance criteria (AC) were used. INTRODUCTION. Introduction PowerPoint Presentation Last modified by: 1. . N. meningitidis is carried harmlessly in the nasopharynx of approximately 5?11% of adults and up to 25% of adolescents. MIC. Neisseria meningitidis, Haemophilus influenzae and Listeria monocytogenes (1) . Filename: Neisseri.ppt Organisms Neisseria meningitidis: meninges (base of the brain) Neisseria gonorrhoeae: primary infection sex organs Branhamella, formerly Neisseria catarrhalis, cocci Moraxella: coccobacilli Kingella: coccobacilli Acinetobacter: coccobacilli N. meningitidis gram negative cocci, capsules, oxidase positive Ontario averages 10 cases per year; 60 in 1994 N. meningitidis in . complex of Neisseria meningitidis ) PRP - T ActHIB OmniHIB Aventis Pasteur Aventis Pasteur Tetanus toxoid Tetanus toxoid * PRP-OMP is also available as a combination vaccine with hepatitis B vaccine (Comvax). Value Set Name: Lab Result (Meningococcal Disease) Value Set OID: 2.16.840.1.114222.4.11.4061: Value Set Description: lab results associated with Meningococcal Disease Herpes 1-8 & VZV (133, 132, 136, 137) 2. Pathology of N meningitidis Neisseria meningitidis (the meningococcus) is a member of the normal nasopharyngeal microbiome in healthy individuals, but can cause septicemia and meningitis in susceptible individuals. . Modification of the rapid fermentation test for Neisseria gonorrhoeae. Common to all of these organisms is the ability to colonize exposed mucosal epithelia. Can also result in brain damage, hearing loss, or learning disabilities. Comparative genomic of several strains of Neisseria meningitidis, a major human pathogen, identified the presence of an 8kb prophage in strains belonging to invasive clonal complexes. Diplococo Gram negativo, inmviles, anaerobios facultativos, oxidasa y catalasa positivo, oxida maltosa y glucosa, crece a 35 C. meningitidis is a common cause of community-acquired bacterial meningitis in both children and adults. Therefore, N meningitidis vaccination is strongly advised before initiating complement C5-blocking therapy. I. PowerPoint Presentation Author: Karzan Mohammad Mortality remains high despite the introduction of vaccinations for common pathogens that have reduced . The genus Neisseria contains the two Gram-negative cocci which are established human pathogens The genus also contains many commensal species, most of which are harmless inhabitants of the upper respiratory and alimentary tracts. Analytic Performance of a Diagnostic Test (cont.) PowerPoint Presentation Last modified by: Lori Tamura N. meningitidis is a fastidious, encapsulated, aerobic gram-negative diplococcus. Although (28)--Neu5Ac is a virulence factor and a protective antigen of these three pathogens, it is also a component of normal tissues (neural cell adhesion molecule . Estos portadores asintomticos son la principal fuente de infeccin, The AURA Surveillance System - 2017. N. gonorrhoeae causes gonorrhea,neonatal conjunctivitis (ophthalmia neonatorum) and pelvic inflammatory disease. With the aim . Neisseria meningitidis (the meningococcus) causes significant morbidity and mortality in children and young adults worldwide through epidemic or sporadic meningitis and/or septicemia. There are between 2000 and 3000 cases of meningococcal meningitis per year in the U.S. This peptide mimics a capsular polysaccharide (CPS) epitope in MenB. The capsular polysaccharide of Neisseria meningitidis A is the major factor of virulence of these bacteria and suffers from poor stability in water. Streptococcus pneumoniae, Neisseria meningitidis, S. agalactiae, Haemophilus influenzae, E. coli. 0 Cases 1 - 2 Cases 3 - 5 Cases > 5 Cases Geography: Title: PowerPoint Presentation Author: Karin Mattiucci Created Date: Very serious, can be deadly. Data from public health systems in Queensland, NSW, ACT, Victoria, Tasmania, South Australia, Western Australia, and private sector in Queensland and northern NSW contributed to the national passive surveillance system (Org TRx) - over 17 million records synology remove storage pool; euro school bannerghatta road; neisseria meningitidis culture media . N. meningitidis causes meningitis and meningococcemia. N.meningitidis is a fastidious, encapsulated, aerobic . PowerPoint Presentation Author: Peter Smith Last modified by: michael.morin Created Date: 5/22/2007 8:20:55 PM Document presentation format: Custom Company: State of Maine - DHS Other titles: Times New Roman Arial Calibri Symbol Microsoft Sans Serif Arial Unicode MS Default Design PowerPoint Presentation Introduction. Bacterial meningitis is a serious inflammation of the meninges caused by various bacteria. N. meningitidis - Epidemic strains/endemic strains - "meningitis" belt in sub-Saharan Africa (type A) Sporadic cases - types B, A, W135, Gram negative (LPS) - Rapid uptake by the epithelial cells - Receptor mediated endocytosis Sepsis Encapsulated - requires IgG + complement to phagocytose Carriers in the population - increased carriage . Neisseria . INTRODUCTION. Our beautiful, affordable PowerPoint templates are used and trusted by both small and large companies around the world. . Neisseria meningitidis (meningococcus) Streptococcus pneumoniae (pneumococcus) Haemophilus influenzae ; Streptococcus agalactiae (group B streptococcus) These bacteria are responsible for more than half of the deaths from meningitis globally and they cause other severe diseases like sepsis and pneumonia. This should not be used for hepatitis B immunization at birth. Neisseria meningitidis (meningococcus) Encapsulated small, gram-negative diplococci Second most common cause (behind S. pneumoniae) of community-acquired meningitis in previously healthy adults; swift progression from good health to life-threatening disease Pathogenicity: Pili-mediated, receptor . In this review, we describe the biology, microbiology, and epidemiology of this exclusive human pathogen. Unusual and severe presentations of MenW infections are common in the current European epidemic. Invasive meningococcal disease is a serious, life-threatening illness, requires prompt medical treatment. Infection of the fluid in the spinal cord and the fluid that surrounds the brain Viral or Bacterial Etiology is important because of the seriousness of the illness and the treatment needed Viral Meningitis Usually clears up in a week or two with no specific treatment Common; rarely serious infection of fluid in . N. meningitidis. PowerPoint Presentation PowerPoint Presentation Reverse Vaccinology PowerPoint Presentation In Silico Analysis Genome sequencing & Identification of vaccine Candidates of Neisseria meningitidis Genome analysis of Neisseria meningitidis serogroup B strain MC58 Neisseria meningitidis (Meningococcus) Comparative Genomics: key to identify the genes . Neisseria meningitidis (the meningococcus) is the causative organism of meningococcal (epidemic) meningitis. Rarer presentations include septic arthritis, pneumonia, pharyngitis and occult bacteraemia There are 13 serogroups of Neisseria meningitidis (the cause of meningococcal disease) in Australia - the 5 most common are A, B, C, W and Y neisseria meningitidis culture media. Neisseria meningitidis: and : Escherichia coli: strains that possess the K1 capsular antigen can be detected by this panel. Infections Caused by The Neisseria Meningitidis Bacteria - Invasive meningococcal disease (IMD) is a life-threatening condition caused by the bacterium Neisseria meningitidis (N. meningitidis), an encapsulated gram-negative diplococcus that is a pathogen exclusive to humans. PowerPoint Presentation Last modified by: 1974 Jun; 27 (6):1027-1030. Further non NG isolates; 13 Neisseria meningitidis (NM), 18 Moraxella catarrhalis (MC) and 2 Kingella dentrificans (KD) were analysed with MALDI-ToF. PowerPoint Presentation Author: Liming Cai Last modified by: Liming Cai Created Date: 10/7/2010 2:54:33 AM Document presentation format: On-screen Show (4:3) Company: University of Georgia Other titles Neisseria meningitidis Diagnosis - rapid -Presence of Gram-negative diplococci in phagocytes of the central nervous system Treatment -Penicillin, administered intravenously, is the drug of choice Prevention -Eradication is unlikely due to the presence of = Range. The pathogenic species are Neisseria meningitidis (meningococcus), a major cause of meningitis and bacteremia, and Neisseria gonorrhoeae (gonococcus), the cause of . In this review, we describe the biology, microbiology, and epidemiology of this exclusive human pathogen. Anatomy Review Central Nervous System Peripheral Nervous System Meninges Blood Brain Barrier Bacterial Meningitis 1. We reviewed the literature that is the basis for our proposal that (28)--Neu5Ac conjugates will be safe and effective vaccines for Group B meningococci (GBMs), Escherichia coli K1, and Pasteurella haemolytica A2. 1. Appl Microbiol. Neisseria meningitidis Neisseria meningitidis Caractersticas Caractersticas Causa diversos tipos de infeccin, la septicemia y la meningitis son los ms frecuentes. View neisseria.ppt from BIO 295 at Emilio Aguinaldo College. The nervous system 2 components: - CNS: brain and spinal cord - PNS: nerves extending from CNS Meningitis- infection of the meninges Encephalitis- infection of the brain Protection via blood-brain barrier Meninges and cerebrospinal fluid Etiologies of bacterial meningitis Neisseria meningitidis, Meningococcal meningitis Symptoms Due to . There are a number of non- pathogenic species, . The analysis of this filamentous bacteriophage, designated MDA for . Bacteria that cause meningococcal disease can also infect the blood, causing septicemia. Meningococcal bacteremia - blood infection. Infection with Neisseria meningitidis can produce a variety of clinical manifestations, ranging from transient fever and bacteremia to fulminant disease with death ensuing within hours of the onset of clinical symptoms.N. Best Neisseria Meningitidis PowerPoint Templates CrystalGraphics is the award-winning provider of the world's largest collection of templates for PowerPoint. In addition, the genus contains a larger number of commensal organisms, including N.lactamica (Nl). Treatment .
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